Murine RARbeta4 displays reduced transactivation activity, lower affinity for retinoic acid, and no anti-AP1 activity.

@article{Soprano2000MurineRD,
  title={Murine RARbeta4 displays reduced transactivation activity, lower affinity for retinoic acid, and no anti-AP1 activity.},
  author={Dianne Robert Soprano and Elizabeth Scanlon and Mohamad Shukri and Zeng Ping Zhang and Kenneth J. Soprano},
  journal={Journal of cellular biochemistry},
  year={2000},
  volume={77 4},
  pages={604-14}
}
The biological actions of retinoic acid (RA) are mediated by retinoic acid receptors (RARalpha, beta, and gamma) and retinoid X receptors (RXR alpha, beta, and gamma). Each of the RARs is expressed as four to seven different isoforms. Four isoforms of RAR beta (beta1, beta2, beta3, and beta4), which differ only in their N-terminal sequence (A domain) have been described. These RARbeta isoforms display a specific pattern of expression in developing and adult animals and are highly evolutionarily… CONTINUE READING