Murine Model of Autoimmune Hearing Loss Induced by Myelin Protein P0

@article{Matsuoka1999MurineMO,
  title={Murine Model of Autoimmune Hearing Loss Induced by Myelin Protein P0},
  author={Hiroshi Matsuoka and K. C. Cheng and Yoshiro Yazawa and Marc S. Krug and Tai June Yoo},
  journal={Annals of Otology, Rhinology \& Laryngology},
  year={1999},
  volume={108},
  pages={255 - 264}
}
Myelin protein P0 has been identified as an autoantigen in inner ear diseases. In order to study autoimmune hearing loss, we performed brain stem auditory-evoked potential (BAEP) studies on P0-sensitized mice. Two P0-sensitized mice showed hunched posture, poor coat, loss of body weight, and abnormal walking with a waddling gait. About 25% of the P0-sensitized mice developed hearing loss. In the BAEP study, peak latencies of waves I, III, and V and the interpeak latency I-III were prolonged in… 
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The results suggest that the EAN animal model can be an effective one for the study of the auditory dysfunction due to demyelination disorders.
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A better animal model of autoimmune inner ear disease (AIED) in Sprague-Dawley rats has been developed by combination with high dose of pertussis toxin, and it is indicated that inner ear-specific antigens can be involved in autoimmune reactions.
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TLDR
Recent progress in understanding the etiology, diagnosis and treatment of autoimmune damage to the inner ear is reviewed.
Immune-mediated inner ear disease
The incidence of autoimmune inner ear disease (AIED) is difficult to determine: probably it is a rare disease, accounting for < 1% of all cases of hearing impairment or dizziness. Nevertheless, the…
Autoimmune Sensorineural Hearing Loss in Young Patients: An Exploratory Study
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The purpose of the present exploratory study was to examine the relationship between the clinical presentation of SNHL among children and young adults and the presence of serum anti‐P0 antibodies.
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References

SHOWING 1-10 OF 34 REFERENCES
Experimental autoimmune sensorineural hearing loss
  • J. Harris
  • Biology, Medicine
    The Laryngoscope
  • 1987
TLDR
Findings are characteristic of autoimmune injury and suggest the establishment of an experimental model of autoimmune sensorineural hearing loss in which to further investigate this clinical disorder.
Myelin protein Po as a potential autoantigen in autoimmune inner ear disease
  • M. Cao, V. Dupriez, J. Tomasi
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1996
TLDR
This data and 2‐dimensional gel electrophoresis followed by immunoblot‐ ting experiments showed that the 30,000 Mr inner ear antigen is the major peripheral myelin protein Po, suggesting that protein Po may be an important autoantigen in autoimmune inner ear disease.
Synergy between antibody and P2-reactive T cells in experimental allergic neuritis
Induction of peripheral tolerance with peptide-specific anergy in experimental autoimmune neuritis.
TLDR
It is demonstrated that SP-26, when coupled to syngeneic spleen cells and administered iv, markedly inhibited development and expression of clinical signs and histological changes of EAN, and the induction of tolerance by this method was peptide-specific and MHC-restricted.
Antibodies against a 30 Kilodalton Cochlear Protein and Type II and IX Collagens in the Serum of Patients with Inner Ear Diseases
TLDR
Anti-type II and anti-type LX antibodies were found in a high percentage of patients with Meniere's disease, otosclerosis, and strial atrophy, and six patients had no detectable antibodies to these proteins by the authors' assay.
T cell responses to myelin proteins in Guillain-Barré syndrome
Inner ear‐specific autoantibodies
TLDR
The sera of patients with idiopathic sensorineural hearing loss were examined, using qualitative immunoblotting (Western blotting), for the presence of inner ear (IE)‐specific autoantibodies, and it is now necessary to purify these IE‐specific antigens and determine their clinical usefulness.
P0 myelin protein produces experimental allergic neuritis in Lewis rats
The protein antigens of peripheral nerve myelin
TLDR
The complete amino acid sequence for P2 has recently been delineated, and its neuritogenic, immunogenic, and antigenic features can now be further characterized.
STUDIES ON EXPERIMENTAL ALLERGIC (ISOIMMUNE) LABYRINTHITIS IN GUINEA PIGS.
By injection of guinea pig cochlea emulsified with Freund's adjuvant, it was possible to induce in the majority of guinea pigs the acoustical and histological disturbances which were interpreted as…
...
...