Murine Model of Autoimmune Hearing Loss Induced by Myelin Protein P0

  title={Murine Model of Autoimmune Hearing Loss Induced by Myelin Protein P0},
  author={Hiroshi Matsuoka and K. C. Cheng and Yoshiro Yazawa and Marc S. Krug and Tai June Yoo},
  journal={Annals of Otology, Rhinology \& Laryngology},
  pages={255 - 264}
Myelin protein P0 has been identified as an autoantigen in inner ear diseases. In order to study autoimmune hearing loss, we performed brain stem auditory-evoked potential (BAEP) studies on P0-sensitized mice. Two P0-sensitized mice showed hunched posture, poor coat, loss of body weight, and abnormal walking with a waddling gait. About 25% of the P0-sensitized mice developed hearing loss. In the BAEP study, peak latencies of waves I, III, and V and the interpeak latency I-III were prolonged in… 

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