Murine Fibroblasts Correlate with p 53 Mutations in Human Lung Tumors

@inproceedings{Liu2005MurineFC,
  title={Murine Fibroblasts Correlate with p 53 Mutations in Human Lung Tumors},
  author={Zhipei Liu and Karl-Rudolf Muehlbauer and Heinz Hans Schmeiser and Manfred Hergenhahn and Djeda Belharazem and Monica C. Hollstein},
  year={2005}
}
Human p53 mutation spectra differ significantly from one cancer type to another. One possible reason is that carcinogenic risk factors differ, and these factors elicit distinct mutation patterns. There has been no mammalian assay, however, with which to generate mutation patterns in human p53 sequences experimentally, hampering interpretation of the human tumor spectra. We have designed a new mammalian cell assay using gene targeting technology that selects and scores human p53 gene sequence… CONTINUE READING
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