Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4+ T cells and diminished adaptive immunity.

@article{Morrison2011MurineCT,
  title={Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4+ T cells and diminished adaptive immunity.},
  author={Sandra G. Morrison and Christina M Farris and Gail L. Sturdevant and William Michael Whitmire and Richard P Morrison},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 8},
  pages={1120-8}
}
Chlamydia muridarum and Chlamydia trachomatis mouse models of genital infection have been used to study chlamydial immunity and vaccine development. To assess the protective role of CD4(+) T cells in resolving C. trachomatis and C. muridarum genital tract infections, we used the female mouse model and evaluated infection in the presence and absence of CD4(+) T cells. In contrast to C. muridarum infection, C. trachomatis infection was unaltered in the absence of CD4(+) T cells. Mice infected… CONTINUE READING

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