Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.

@article{Fan2007MurineCI,
  title={Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.},
  author={Xuedong Fan and Andriani C. Patera and Amy Pong-Kennedy and Gregory S. Deno and Waldemar Gonsiorek and Denise J. Manfra and Galya Vassileva and Ming Zeng and Craig Jackson and Lee Sullivan and Wanda Sharif-Rodriguez and Ghislain Opdenakker and J R Van Damme and Joseph A. Hedrick and Daniel Lundell and Sergio A Lira and Richard William George. Hipkin},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 16},
  pages={
          11658-66
        }
}
Functional interleuin-8 (IL-8) receptors (IL-8RA and IL-8RB: CXCR1 and CXCR2, respectively) have been described in human, monkey, dog, rabbit, and guinea pig. Although three IL-8R homologues have been found in rat, only one of these, rat CXCR2, appears to be functional based on responsiveness to ligands. Similarly, CXC chemokines induce biological responses through the murine homolog of CXCR2, but the identification of functional rodent CXCR1 homologues has remained elusive. We have identified… CONTINUE READING
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