Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene.

@article{Su2004MurineCR,
  title={Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene.},
  author={Leon L Su and R{\'e}mi J Creusot and Elena M. Gallo and Steven K. M. Chan and Paul Joseph Utz and C. Garrison Fathman and Joerg Ermann},
  journal={Journal of immunology},
  year={2004},
  volume={173 8},
  pages={4994-5001}
}
CD4+CD25+ regulatory T cells (Treg) acquire unique immunosuppressive properties while maintaining an anergy phenotype when activated in vitro under conditions that induce IL-2 production and proliferation in conventional CD4+ T cells. We investigated the mechanism underlying one component of this naturally anergic phenotype, the inability of the Treg cells to produce IL-2 following activation. Analysis of freshly isolated murine CD4+CD25+ Treg and conventional CD4+CD25- T cells following PMA… CONTINUE READING

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