Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production

  title={Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production},
  author={G J Freeman and Frank Borriello and Richard J Hodes and Hans Reiser and John G Gribben and John KC. Chan William Y. W. Tsang CS. Ng and Jihee Kim and Jonathan M. Goldberg and Karen S. Hathcock and Gl{\'o}ria L{\'a}szl{\'o}},
  journal={The Journal of Experimental Medicine},
  pages={2185 - 2192}
The B7-1 molecule, expressed on antigen presenting cells (APC), provides a crucial costimulatory signal for T cell activation. Recent studies demonstrate the existence of alternative, non-B7-1 CTLA4 counter-receptors in mice and humans. Here, we describe the molecular cloning and demonstrate costimulatory function of the murine B7-2 (mB7-2) gene. Murine B7-2 cDNA encodes a member of the Ig supergene family that binds CTLA4-Ig and stains with the GL1 but not anti-mB7-1 mAb. Murine B7-2… CONTINUE READING


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