Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosis.

@article{Macrae2003MuridH4,
  title={Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosis.},
  author={Alastair Ian Macrae and Edward J. Usherwood and Syed Mazher Husain and Emilio Fla{\~n}o and In-Jeong Kim and David L. Woodland and Anthony Nash and Marcia A Blackman and Jeffery T. Sample and J. P. Stewart},
  journal={Journal of virology},
  year={2003},
  volume={77 17},
  pages={
          9700-9
        }
}
This work describes analyses of the function of the murid herpesvirus 4 strain 68 (MHV-68) M2 gene. A frameshift mutation was made in the M2 open reading frame that caused premature termination of translation of M2 after amino acid residue 90. The M2 mutant showed no defect in productive replication in vitro or in lungs after infection of mice. Likewise, the characteristic transient increase in spleen cell number, Vbeta4 T-cell-receptor-positive CD8(+) T-cell mononucleosis, and establishment of… CONTINUE READING

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