Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism.

@article{Hu2014MuricholicBA,
  title={Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism.},
  author={Xiaochen Hu and Ylva Bonde and G{\"o}sta Eggertsen and M Rudling},
  journal={Journal of internal medicine},
  year={2014},
  volume={275 1},
  pages={27-38}
}
OBJECTIVE Bile acid (BA) synthesis is regulated by negative feedback end-product inhibition, initiated by farnesoid X receptors (FXRs) in liver and gut. Studies on cholic acid (CA)-free Cyp8b1(-/-) mice have concluded that CA is a potent suppressor of BA synthesis. Cyp8b1(-/-) mice have increased BA synthesis and an enlarged BA pool, a phenotype shared with bile-duct-ligated, antibiotics-administered and with germ-free mice. Studies on such mice have concluded BA synthesis is induced due to… CONTINUE READING
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