Mupirocin for the reduction of colonization of internal jugular cannulae--a randomized controlled trial.

@article{Hill1990MupirocinFT,
  title={Mupirocin for the reduction of colonization of internal jugular cannulae--a randomized controlled trial.},
  author={Robert L R Hill and A. P. Fisher and Robert J. Ware and S. Wilson and M. W. Casewell},
  journal={The Journal of hospital infection},
  year={1990},
  volume={15 4},
  pages={
          311-21
        }
}
In a prospective study, 218 cardiothoracic patients, in whom 'Abbocath-T' cannulae had been inserted preoperatively into the internal jugular vein, were randomized to receive skin preparation of the insertion site with tincture of iodine (108 controls) or tincture of iodine followed by application of sterile 2% calcium mupirocin ointment (110 test patients). Cannulae were usually removed within 48 h of the operation. Patients receiving mupirocin were less likely to develop significant… Expand
Reduction in the colonization of central venous cannulae by mupirocin.
TLDR
In an in-vitro simulation of an intravascular cannula enclosed in a fibrin sheath, 0.03 mg1(-1) of mupirocin prevented significant colonization by two clinical isolates of Staphylococcus epidermidis and one each of S. saprophyticus, S. hominis and S. haemolyticus. Expand
A randomized controlled trial of topical exit site mupirocin application in patients with tunnelled, cuffed haemodialysis catheters.
  • D. Johnson, R. Macginley, +4 authors P. Hollett
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2002
TLDR
Thrice-weekly application of mupirocin to tunnelled, cuffed haemodialysis catheter exit sites is associated with a marked reduction in line-related sepsis and a prolongation of catheter survival and was not associated with any adverse patient effects or the induction of antimicrobial resistance. Expand
Double-blind prospective randomized study comparing topical mupirocin and placebo for the prevention of infection associated with central venous catheters.
TLDR
It is suggested that patients receiving topical mupirocin at the exit site for long term central venous catheters have significantly less local catheter-related infection, and there is a trend towards less catheter -related bacteremia. Expand
Staphylococcus aureus prophylaxis in hemodialysis patients using central venous catheter: effect of mupirocin ointment.
TLDR
Mupirocin applied to the insertion site significantly reduces the risk of Staphylococcus aureus skin and catheter colonization, exit-site infection, and StaphlyococcusAureus bacteremia in hemodialysis patients. Expand
Minimal dose requirements for nasal mupirocin and its role in the control of epidemic MRSA.
TLDR
It is found that a single dose, or a regimen of 4-times daily for 2 days, eliminated nasal carriage of S. aureus within 24 h; 7 days after a single doses, 92% of the subjects were still cleared; 7 Days after the 2-day course, 96% remained free of nasal S.Aureus. Expand
Pathogenesis of infections related to intravascular catheterization
Over the past few decades, there have been major technological improvements in the manufacture of intravenous solutions and the manufacture and design of catheter materials. However, the risk ofExpand
No evidence that medicinal honey reduces bacterial skin colonisation at a peripheral catheter insertion site in dogs.
TLDR
Topical application of a medicinal honey did not reduce bacterial skin colonisation at the insertion site of peripheral catheters in dogs and few catheter-associated complications were observed. Expand
A randomized trial of Staphylococcus aureus prophylaxis in peritoneal dialysis patients: mupirocin calcium ointment 2% applied to the exit site versus cyclic oral rifampin.
TLDR
It is concluded that mupirocin ointment at the exit site and cyclic oral rifampin are equally effective in reducing S aureus catheter infections. Expand
Skin antisepsis for reducing central venous catheter-related infections.
TLDR
There was no clear evidence of a difference in all outcomes examined, including catheter-related BSI, septicaemia, catheter colonisation and number of patients who required systemic antibiotics for any of the three comparisons involving three different antisepsis regimens. Expand
Central venous catheter bloodstream infections in the neonatal intensive care unit.
TLDR
Fever and pulmonary dysfunction were the most common signs of CVC BSI in neonates and concerns regarding the emergence of vancomycin-resistant organisms preclude support of its use as a prophylactic agent. Expand
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TLDR
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