MupB, a new high-level mupirocin resistance mechanism in Staphylococcus aureus.

@article{Seah2012MupBAN,
  title={MupB, a new high-level mupirocin resistance mechanism in Staphylococcus aureus.},
  author={Christine Seah and David C. Alexander and Lisa Louie and Andrew E. Simor and Donald Edward Low and Jean Longtin and Roberto G Melano},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 4},
  pages={1916-20}
}
Mupirocin is a topical antibiotic used for the treatment of skin infections and the eradication of methicillin-resistant Staphylococcus aureus carriage. It inhibits bacterial protein synthesis by interfering with isoleucyl-tRNA synthetase activity. High-level mupirocin resistance (MIC of ≥ 512 μg/ml) is mediated by the expression of mupA (ileS2), which… CONTINUE READING