Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

@inproceedings{Jewell2011Munc18cPB,
  title={Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis},
  author={Jenna L Jewell and Eunjin Oh and Latha Ramalingam and Michael A Kalwat and Vincent S. Tagliabracci and Lixuan Tackett and Jeffrey S. Elmendorf and Debbie C Thurmond},
  booktitle={The Journal of cell biology},
  year={2011}
}
How the Sec1/Munc18-syntaxin complex might transition to form the SNARE core complex remains unclear. Toward this, Munc18c tyrosine phosphorylation has been correlated with its dissociation from syntaxin 4. Using 3T3-L1 adipocytes subjected to small interfering ribonucleic acid reduction of Munc18c as a model of impaired insulin-stimulated GLUT4 vesicle exocytosis, we found that coordinate expression of Munc18c-wild type or select phosphomimetic Munc18c mutants, but not phosphodefective mutants… CONTINUE READING

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