Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis

@inproceedings{Qin2017Munc18bII,
  title={Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis},
  author={Tairan Qin and Tao Liang and Dan Zhu and Youhou Kang and Li Xie and Subhankar Dolai and Shuzo Sugita and Noriko Takahashi and C. G. Ostenson and Kate Banks and Herbert Y Gaisano},
  booktitle={EBioMedicine},
  year={2017}
}
Reduced pancreatic islet levels of Munc18a/SNARE complex proteins have been postulated to contribute to the deficient glucose-stimulated insulin secretion (GSIS) in type-2 diabetes (T2D). Whereas much previous work has purported Munc18a/SNARE complex (Syntaxin-1A/VAMP-2/SNAP25) to be primarily involved in predocked secretory granule (SG) fusion, less is known about newcomer SGs that undergo minimal docking time at the plasma membrane before fusion. Newcomer SG fusion has been postulated to… CONTINUE READING

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