Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.

  title={Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.},
  author={Cristiana Brochetta and Ryo Suzuki and F. Vita and Maria Rosa Soranzo and Julien Claver and Lydia Celia Madjene and Tarik Attout and Joana Vitte and Nadine Varin-Blank and G. Zabucchi and Juan Francisco Rivera and Ulrich Blank},
  journal={Journal of immunology},
  volume={192 1},
Mast cell degranulation requires N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) and mammalian uncoordinated18 (Munc18) fusion accessory proteins for membrane fusion. However, it is still unknown how their interaction supports fusion. In this study, we found that small interfering RNA-mediated silencing of the isoform Munc18-2 in mast cells inhibits cytoplasmic secretory granule (SG) release but not CCL2 chemokine secretion. Silencing of its SNARE-binding partner syntaxin… CONTINUE READING

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