Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.

@article{Ciufo2005Munc181RE,
  title={Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.},
  author={Leonora F. Ciufo and Jeff W Barclay and Robert D. Burgoyne and Alan Morgan},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 2},
  pages={
          470-82
        }
}
Sec1/Munc18 (SM) proteins are involved in various intracellular membrane trafficking steps. Many SM proteins bind to appropriate syntaxin homologues involved in these steps, suggesting that SM proteins function as syntaxin chaperones. Organisms with mutations in SM genes, however, exhibit defects in either early (docking) or late (fusion) stages of exocytosis, implying that SM proteins may have multiple functions. To gain insight into the role of SM proteins, we introduced mutations modeled on… CONTINUE READING