Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.

@article{Zhu2008Munc132BS,
  title={Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.},
  author={Yunxiang Zhu and Camille Ehr{\'e} and Lubna H. Abdullah and John Kieran Sheehan and Michelle Roy and Christopher M Evans and Burton F Dickey and Christiana W Davis},
  journal={The Journal of physiology},
  year={2008},
  volume={586 7},
  pages={1977-92}
}
Since the airways of control mouse lungs contain few alcian blue/periodic acid-Schiff's (AB/PAS)+ staining 'goblet' cells in the absence of an inflammatory stimulus such as allergen sensitization, it was surprising to find that the lungs of mice deficient for the exocytic priming protein Munc13-2 stain prominently with AB/PAS under control conditions. Purinergic agonists (ATP/UTP) stimulated release of accumulated mucins in the Munc13-2-deficient airways, suggesting that the other airway… CONTINUE READING

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