Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine.

@article{Tam2001MultiwavelengthSR,
  title={Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine.},
  author={Kin Yip Tam and L Qu{\'e}r{\'e}},
  journal={Analytical sciences : the international journal of the Japan Society for Analytical Chemistry},
  year={2001},
  volume={17 10},
  pages={1203-8}
}
The acid-base properties of the antihistamine (H1 receptor antagonist) cetirizine have been studied by using a previously developed multiwavelength spectrophotometric titration method. A new computational procedure called "Two-Step-Divide-and-Conquer" (TSDC), which applied evolving factor analysis (EFA) and target factor analysis (TFA), has been derived to unravel the micro-equilibria of the triprotic zwitterionic compound from the spectral data. We have demonstrated that a single… CONTINUE READING