Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans.

@article{Xu2004MultivesicularBC,
  title={Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans.},
  author={Wenjie Xu and Frank J Smith and Ryan L Subaran and Aaron P. Mitchell},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 12},
  pages={
          5528-37
        }
}
The ESCRT-I, -II, and -III protein complexes function to create multivesicular bodies (MVBs) for sorting of proteins destined for the lysosome or vacuole. Prior studies with Saccharomyces cerevisiae have shown that the ESCRT-III protein Snf7p interacts with the MVB pathway protein Bro1p as well as its homolog Rim20p. Rim20p has no role in MVB formation, but functions in the Rim101p pH-response pathway; Rim20p interacts with transcription factor Rim101p and is required for the activation of… CONTINUE READING
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