• Corpus ID: 5016168

Multivariate statistical modelling of the pharmaceutical process of wet granulation and tableting

  title={Multivariate statistical modelling of the pharmaceutical process of wet granulation and tableting},
  author={Johan A. Westerhuis},
Wet granulation in high-shear mixers is a process of particle size enlargement much used in the pharmaceutical industry to improve the tableting properties of powder mixtures, such as flowability and compactibility, necessary for the large scale production of pharmaceutical talbets. ... Zie: Summary 

Figures and Tables from this paper

Multiphase versus Single Pot Granulation Process: Influence of Process and Granulation Parameters on Granules Properties
The aim of this review is to present the influence of equipment, process, and formulation parameters on granules properties, considering both the granulation and the drying steps of multiphase and single pot processes.
Comparison of single pot and multiphase high shear wet granulation processes related to excipient composition.
Investigations on formulations manufactured both in a single pot mixer-granulator-dryer and in a multiphase equipment showed that both processes led to products with similar characteristics which demonstrated the ability of the processes to produce granules with close quality.
Multivariate methods in tablet formulation
This thesis describes the application of multivariate methods in a novel approach to the formulation of tablets for direct compression. It begins with a brief historical review, followed by a basic
Chemometric Methods in Pharmaceutical Tablet Development and Manufacturing Unit Operations
The feasibility and power of multivariate data analysis in case of analysis and evaluation of tablet development and manufacturing unit operations is shown.
Dynamic Process Monitoring of an Ammonia Synthesis Fixed-Bed Reactor
Abstract—This study involves the modeling and monitoring of an ammonia synthesis fixed-bed reactor using partial least squares (PLS) and its variants. The process exhibits complex dynamic behavior
Mean Particle Diameters. Part VII. The Rosin‐Rammler Size Distribution: Physical and Mathematical Properties and Relationships to Moment‐Ratio Defined Mean Particle Diameters
The Rosin‐Rammler particle size distribution is used for a broad range of applications. Physical and statistical properties of the Rosin‐Rammler distribution and its parameters were investigated to
  • M. Alderliesten
  • Environmental Science
    Journal of biopharmaceutical statistics
  • 2005
An empirical method to select the proper type of mean diameter to describe a physical, chemical, or physiological property of a product or material containing dispersed phases is dealt with.
Mean Particle Diameters. Part VI: Fundamental Distinction between Statistics Based (ISO/DIN) and Physics Based (Moment‐Ratio) Definition Systems
Two methods to define mean particle diameters exist, viz., the statistics based ISO/DIN method and the physics based Moment‐Ratio (M‐R) method. The ISO/DIN method characterizes a size distribution by
Schwingungsspektroskopische Untersuchungen photoinduzierter Acrylatpolymerisationen
Im Rahmen dieser Dissertation wurde die photochemisch initiierte mit Ethylenglykoldimethacrylat vernetzende Methacrylsaurepolymerisation mit der Raman-, Nahinfrarot- (NIR) und der Abgeschwachten


Optimization of a Granulation Procedure for a Hydrophilic Matrix Tablet Using Experimental Design
An experimental design was used in order to optimize a granulation procedure in a high-shear mixer for a hydrophilic matrix tablet formulation. The parameters tested were the amount of water in the
Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. I. Physical Properties of Granules for Tableting
Several kinds of theophylline granules were prepared by monitoring the power consumption of a high speed mixer while compressing them into tablets. The physical properties of the granules and their
Optimizing the Friability of a Tablet Formulation
AbstractThe impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was
Optimization of granulates in a high shear mixer by mixture design
AbstractOptimization of wet granulation in a 10 litre high shear mixer was examined by mixture design. Lactose, corn starch and cellulose microcrystalline were used as eccipients of the granules.
Wet granulation in a small scale high shear mixer
AbstractWet granulation of lactose and corn starch in a 10 litre high shear mixer was examined. The effect of the amount of water added, granulation time and impeller speed on five properties of the
Granulation of Lactose in a Recording High-Speed Mixer, Diosna P25
AbstractWhen the conditions involved in the granulation process — inter alia liquid flow rate, atomization conditions, impeller and chopper speed, and amount of powder — were fixed, it was possible
The granulation of ternary mixtures: the effect of the wettability of the powders
The mean granule sizes and resistance to crushing of the granules increased as the wettability of the third component increased and the detailed results are discussed in relation to powder wetting and the packing properties of powder mixtures.
Granulation with a high-speed mixer-granulator-dryer: optimization of the process
Le but de cette etude est d'optimiser le procede de granulation employant un melangeur-granulateur-sechoir tournant a grande vitesse. Le lactose pulverise et l'amidon, ainsi que la gelatine standard
Influence of Liquid Bonding Strength on Power Consumption During Granulation in a High Shear Mixer
AbstractA comparison between the effects of different binders on power consumption and -granule growth by granulation in a Fielder PMAT 25 high shear mixer demonstrates that the power consumption is