Multivariate measurement of gene expression relationships.

@article{Kim2000MultivariateMO,
  title={Multivariate measurement of gene expression relationships.},
  author={S. Kim and Edward R. Dougherty and Y. Chen and Krishnamoorthy Sivakumar and Paul S. Meltzer and Jeffery M. Trent and M.L. Bittner},
  journal={Genomics},
  year={2000},
  volume={67 2},
  pages={
          201-9
        }
}
The operational activities of cells are based on an awareness of their current state, coupled to a programmed response to internal and external cues in a context-dependent manner. One key goal of functional genomics is to develop analytical methods for delineating the ways in which the individual actions of genes are integrated into our understanding of the increasingly complex systems of organelle, cell, organ, and organism. This paper describes a novel approach to assess the codetermination… 
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A general statistical approach to finding associations between the expression patterns of genes via the coefficient of determination, which measures the degree to which the transcriptional levels of an observed gene set can be used to improve the prediction of the transcriptionAL state of a target gene relative to the best possible prediction in the absence of observations.
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