Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment

@article{Teipel2007MultivariateDA,
  title={Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment},
  author={Stefan J. Teipel and Christine Born and Michael Ewers and Arun L. W. Bokde and Maximilian Reiser and Hans-J{\"u}rgen M{\"o}ller and Harald Hampel},
  journal={NeuroImage},
  year={2007},
  volume={38 1},
  pages={13-24}
}
Automated deformation-based analysis of MRI scans can be used to detect specific pattern of brain atrophy in Alzheimer's disease (AD), but it still lacks an established model to derive the individual risk of AD in at-risk subjects, such as patients with mild cognitive impairment (MCI). We applied principal component analysis to deformation maps derived from MRI scans of 32 AD patients, 18 elderly healthy controls and 24 MCI patients. Principal component scores were used to discriminate between… CONTINUE READING