Multivariate analysis of prognostic factors in fulminant hepatitis B

@article{Bernuau1986MultivariateAO,
  title={Multivariate analysis of prognostic factors in fulminant hepatitis B},
  author={Jacques R Bernuau and Alain Goudeau and T. Poynard and Frédéric Dubois and G{\'e}rard Lesage and Bernard Yvonnet and Claude Degott and Annie Bezeaud and Bernard Rueff and Jean Pierre Benhamou},
  journal={Hepatology},
  year={1986},
  volume={6}
}
We assessed prognostic factors in 115 patients with serologically defined fulminant hepatitis B. The diagnosis in each case was based on the finding of IgM antibody to the hepatitis B core antigen in serum. Multivariate analysis showed that factor V level (p < 0.001), patient's age (p = 0.001), absence of detectable HBsAg by radioimmunoassay (p = 0.06) and serum α‐fetoprotein concentration (p = 0.07) were independent predictors of survival. The survival rate in the 21 patients in whom HBsAg was… 
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Most of patients with FHF might have been caused by hepatotropic viral infection, and non‐A, non‐B virus(es) seems to be the dominant hepatotropic Viral Viral infection among these patients.
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Within the first 15 years of universal vaccination, HBV was found to rarely cause FHF in children age > 1 year but remained a significant cause of F HF in infants.
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TLDR
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TLDR
The factors adversely affecting theoutcome in patients with FHF complicating viral hepatitis include presence of overt clinical features of raised ICP at the time of hospitalization, prothrombin time on admission, age (>50yr), and onset of encephalopathy seven days after onset of jaundice.
Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus
TLDR
The results indicate that HBV mutants incapable of translating hepatitis B e antigen would play a major role in fulminant hepatic failure occurring after acute HBV infection, and HBV variants with core promoter mutations for reducing the transcription of hepatitis B E antigen will play an additional role in Fulminant Hepatic failure developing during chronic infection.
Accurate prediction of fulminant hepatic failure in severe acute viral hepatitis: multicenter study
TLDR
It is indicated that fulminant hepatic failure can be predicted, by a simple discrimination equation, at the stage of severe acute hepatitis.
Characteristics of patients dying from acute viral hepatitis in Serbia.
  • N. Svirtlih, D. Delić, I. Boricic
  • Medicine, Biology
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • 2011
TLDR
Hepatitis B virus infection, severe impairment of liver function tests, and confluent hepatocyte necrosis and infection characterize patients dying from acute viral hepatitis in Serbia.
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