Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells

Abstract

Sprouting of angiogenic perivascular cells is thought to be highly dependent upon autocrine and paracrine growth factor stimulation. Accordingly, we report that corneal angiogenesis induced by ectopic FGF implantation is strongly impaired in NG2/CSPG4 proteoglycan (PG) null mice known to harbour a putative deficit in pericyte proliferation/mobilization… (More)
DOI: 10.1007/s10456-012-9316-7

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