Multivalent nanoparticle networks enable point-of-care detection of human phospholipase-A2 in serum.

@article{Chapman2015MultivalentNN,
  title={Multivalent nanoparticle networks enable point-of-care detection of human phospholipase-A2 in serum.},
  author={Robert Clark Chapman and Yiyang Lin and Mark Burnapp and Andrew Bentham and David Nathan Hillier and Abigail Zabron and Shahid A.A. Khan and Matthew Tyreman and Molly M Stevens},
  journal={ACS nano},
  year={2015},
  volume={9 3},
  pages={
          2565-2573
        }
}
A rapid and highly sensitive point-of-care (PoC) lateral flow assay for phospholipase A2 (PLA2) is demonstrated in serum through the enzyme-triggered release of a new class of biotinylated multiarmed polymers from a liposome substrate. Signal from the enzyme activity is generated by the adhesion of polystreptavidin-coated gold nanoparticle networks to the lateral flow device, which leads to the appearance of a red test line due to the localized surface plasmon resonance effect of the gold. The… CONTINUE READING
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