Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin.


Cyanovirin-N (CV-N) is a cyanobacterial lectin that binds to specific oligomannoses on the surface of gp120, resulting in nanomolar antiviral activity against HIV. In its monomeric form, CV-N contains two functional carbohydrate-binding domains, A and B. When refolded at high concentration, the protein can form a domain-swapped dimer. To clarify the role of… (More)
DOI: 10.1002/bip.21173


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