Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions.


Multivalent inhibitors of the cholera toxin B pentamer are potential therapeutic drugs for treating cholera and serve as models for demonstrating multivalent ligand effects through a structure-based approach. A crucial yet often overlooked aspect of multivalent drug design is the length, rigidity and chemical composition of the linker used to connect… (More)
DOI: 10.1111/j.1747-0285.2008.00648.x


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