Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels.

@article{Huh2012MultivalentDR,
  title={Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels.},
  author={Jae-Wan Huh and Jun Wu and Chul-Hwan Lee and Miyong Yun and Daniel Gilada and Chad A. Brautigam and Bing Nan Li},
  journal={The EMBO journal},
  year={2012},
  volume={31 17},
  pages={3564-74}
}
The Rpd3S histone deacetylase complex represses cryptic transcription initiation within coding regions by maintaining the hypo-acetylated state of transcribed chromatin. Rpd3S recognizes methylation of histone H3 at lysine 36 (H3K36me), which is required for its deacetylation activity. Rpd3S is able to function over a wide range of H3K36me levels, making this a unique system to examine how chromatin regulators tolerate the reduction of their recognition signal. Here, we demonstrated that Rpd3S… CONTINUE READING
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