Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy

@inproceedings{Sarangthem2016MultivalentTB,
  title={Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier
for Effective Cancer Therapy},
  author={Vijaya Sarangthem and Yunjae Kim and Thoudam Debraj Singh and Bo-Yeon Seo and Sun-Ha Cheon and Young-Jin Lee and Byungheon Lee and R K Park},
  booktitle={Theranostics},
  year={2016}
}
Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities of the drug conjugates. Herein, we described a unique delivery system comprised of genetically engineered ELP incorporated with multiple copies of IL-4 receptor targeting peptide… CONTINUE READING

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