Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.

  title={Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.},
  author={Taverekere S Girish and Robert K. McGinty and Song Tan},
  journal={Journal of molecular biology},
  volume={428 8},
Set8 is the only mammalian monomethyltransferase responsible for H4K20me1, a methyl mark critical for genomic integrity of eukaryotic cells. We present here a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex. Our studies indicate that Set8 employs its i-SET and c-SET domains to engage nucleosomal DNA 1 to 1.5 turns from the nucleosomal dyad and in doing so, it positions… CONTINUE READING


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