Multivalent HSA conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection.

@article{Johansson2005MultivalentHC,
  title={Multivalent HSA conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection.},
  author={Susanne M C Johansson and Niklas Arnberg and Mikael Elofsson and G{\"o}ran Wadell and Jan Kihlberg},
  journal={Chembiochem : a European journal of chemical biology},
  year={2005},
  volume={6 2},
  pages={358-64}
}
Adenoviruses of serotypes 8, 19 and 37 are the major cause of the severe eye infection EKC (epidemic keratoconjunctivitis). In general, all adenoviruses interact with their cellular receptors through the fibre proteins, which extend from the virus particle. Recently, adenovirus type 37 (Ad37) was found to bind and infect human corneal cells through attachment to carbohydrate structures that carry terminal alpha-(2-3)-linked sialic acids. Herein we present a synthetic route to a 3'-sialyllactose… CONTINUE READING

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