Multivalent Dendritic Molecules as Broad Spectrum Bacteria Agglutination Agents

@article{Xiao2013MultivalentDM,
  title={Multivalent Dendritic Molecules as Broad Spectrum Bacteria Agglutination Agents},
  author={Shuzhang Xiao and Lica Abu-Esba and Serhan Turkyilmaz and Alexander G. White and Bradley D. Smith},
  journal={Theranostics},
  year={2013},
  volume={3},
  pages={658 - 666}
}
This study reports the first set of synthetic molecules that act as broad spectrum agglutination agents and thus are complementary to the specific targeting of antibodies. The molecules have dendritic architecture and contain multiple copies of zinc(II)-dipicolylamine (ZnDPA) units that have selective affinity for the bacterial cell envelope. A series of molecular structures were evaluated, with the number of appended ZnDPA units ranging from four to thirty-two. Agglutination assays showed that… 

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