Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection.

@article{Wang2010MultivalentDV,
  title={Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection.},
  author={Chengmin Wang and Jing Luo and Said Amer and Yunhai Guo and Yi Hu and Yanmin Lu and Haijing Wang and Mingxing Duan and Hongxuan He},
  journal={Vaccine},
  year={2010},
  volume={29 2},
  pages={323-8}
}
The aim of this work was to evaluate efficiency as well as the type of immune response, Th1 or Th2, induced by multivalent DNA vaccinations in C57BL/6 interleukin-12p40 (IL-12p40) knockout (KO) mice. A recombinant pVAX-15-23 plasmid DNA was constructed by inserting surface glycoprotein (cp15- and p23)-encoding DNA into the pVAX1 expression vector. Various parameters including antibody and cytokine responses, proliferation assay and oocyst shedding were used to evaluate the type of immune… CONTINUE READING