Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities

@inproceedings{Liu2010MultivalentAP,
  title={Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities},
  author={Shouping Liu and Lei Zhou and Rajamani Lakshminarayanan and R. W. Beuerman},
  booktitle={International Journal of Peptide Research and Therapeutics},
  year={2010}
}
This review highlights the design principles, progress and advantages attributed to the structural diversity associated with both natural and synthetic multivalent antimicrobial peptides (AMPs). Natural homo- or hetero-dimers of AMPs linked by intermolecular disulfide bonds existed in the animal kingdom, but the multivalency strategy has been adopted to create synthetic branched or polymeric AMPs that do not exist in nature. The multivalent strategy for the design of multivalent AMPs provides… CONTINUE READING
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