Multivalency effects in protein--carbohydrate interaction: the binding of the Shiga-like toxin 1 binding subunit to multivalent C-linked glycopeptides.

@article{Lundquist2000MultivalencyEI,
  title={Multivalency effects in protein--carbohydrate interaction: the binding of the Shiga-like toxin 1 binding subunit to multivalent C-linked glycopeptides.},
  author={Joseph J Lundquist and Sheryl D Debenham and Eric J. Toone},
  journal={The Journal of organic chemistry},
  year={2000},
  volume={65 24},
  pages={8245-50}
}
A series of monovalent and bivalent glycopeptides displaying a C-linked analogue of the Pk trisaccharide, the in vivo ligand for the pentavalent Shiga-like toxin binding subunit (SLT-1B), were prepared and evaluated as ligands for SLT-1B by isothermal titration microcalorimetry and competitive enzyme-linked immunosorbent assay (ELISA). Although none of the… CONTINUE READING