Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain.

@article{Sakamoto1998MultitissueCE,
  title={Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain.},
  author={Kunihiro Sakamoto and Takahiro Nagase and Hiroshi Fukui and Kazumasa Horikawa and Taro Okada and Hirofumi Tanaka and Kanako Sato and Yasuyuki Miyake and Osamu Ohara and Koichiro Kako and Norio Ishida},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 42},
  pages={27039-42}
}
The period (per) gene, controlling circadian rhythms in Drosophila, is expressed throughout the body in a circadian manner. A homolog of Drosophila per was isolated from rat and designated as rPer2. The rPER2 protein showed 39 and 95% amino acid identity with mPER1 and mPER2 (mouse homologs of per) proteins, respectively. A robust circadian fluctuation of rPer2 mRNA expression was discovered not only in the suprachiasmatic nucleus (SCN) of the hypothalamus but also in other tissues including… CONTINUE READING