Multitargeted therapy of cancer by silymarin.

@article{Ramasamy2008MultitargetedTO,
  title={Multitargeted therapy of cancer by silymarin.},
  author={Kumaraguruparan Ramasamy and Rajesh Agarwal},
  journal={Cancer letters},
  year={2008},
  volume={269 2},
  pages={
          352-62
        }
}
Silymarin, a flavonolignan from milk thistle (Silybum marianum) plant, is used for the protection against various liver conditions in both clinical settings and experimental models. In this review, we summarize the recent investigations and mechanistic studies regarding possible molecular targets of silymarin for cancer prevention. Number of studies has established the cancer chemopreventive role of silymarin in both in vivo and in vitro models. Silymarin modulates imbalance between cell… Expand
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Silymarin is a chemopreventive agent in vivo against a variety of carcinogens/tumor promoters, including UV light, 7,12-dimethylbenz(a)anthracene (DMBA), phorbol 12-myristate 13-acetate (PMA) and others. Expand
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An overview of the current clinical applications of milk thistle in the oncology setting, including guidelines on commonly used forms and doses is provided. Expand
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