Multisystem failure: the story of anti-influenza drugs

@article{Jefferson2014MultisystemFT,
  title={Multisystem failure: the story of anti-influenza drugs},
  author={Tom Jefferson and Peter Doshi},
  journal={BMJ : British Medical Journal},
  year={2014},
  volume={348}
}
Last year the Cochrane team, with the help of the BMJ’s open data campaign, finally got access to full clinical study reports on neuraminidase inhibitors. Tom Jefferson and Peter Doshi explain what the new systematic review found and how a series of failures meant that decisions about these drugs were made without the full evidence 

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The evidence fails to support the mechanism of action mediated through antiviral action put forward by the manufacturers, and it is found that symptom relief occurs in a whole population with influenzalike symptoms many of whom will not have influenza.

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Dunning questions the relevance of our systematic review, suggesting that any research data—regardless of its quality—that tests the effect of neuraminidase inhibitors on non-pandemic influenza

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  • J. Dunning
  • Medicine
    BMJ : British Medical Journal
  • 2014
The latest Cochrane review of neuraminidase inhibitors for influenza was impressive but did not investigate antiviral effectiveness in severe influenza, illness caused by pandemic H1N1.

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Financial Conflicts of Interest and Conclusions About Neuraminidase Inhibitors for Influenza

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The Tamiflu fiasco and lessons learnt

This article takes a comprehensive relook on the Tamiflu saga, and suggests some ways and means to avoid a similar situation in the future.

Ebola in west Africa.

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Neuraminidase Inhibitors in Influenza Treatment and Prevention–Is It Time to Call It a Day?

A mathematical model of influenza infection was used and it was indicated that contributions of oseltamivir to epidemic control could be high, but were observed only in fragile settings and the efficacy was limited by design.
...

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