Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.

  title={Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.},
  author={Scott C. Fears and Susan K. Service and Barbara Kremeyer and Carmen Araya and Xinia Araya and Julio Bejarano and Margarita Ramirez and Gabriel Castrill{\'o}n and Juliana Gomez-Franco and Mar{\'i}a del Carmen L{\'o}pez and Gabriel Jaime Montoya Montoya and Patricia Montoya and Ileana Aldana and T. M. Teshiba and Zvart Abaryan and N B Al-Sharif and Marissa Ericson and Maria Jalbrzikowski and Jurjen Justin Luykx and Linda Navarro and Todd A. Tishler and Lori L. Altshuler and George Bartzokis and Javier I. Escobar and David C. Glahn and Jorge Ospina-Duque and Neil J. Risch and Andres Ruiz-Linares and Paul M. Thompson and Rita M. Cantor and Carlos L{\'o}pez-Jaramillo and Gabriel Macaya and Julio A. Molina and Victor I. Reus and Chiara Sabatti and Nelson B. Freimer and Carrie E. Bearden},
  journal={JAMA psychiatry},
  volume={71 4},
IMPORTANCE Genetic factors contribute to risk for bipolar disorder (BP), but its pathogenesis remains poorly understood. A focus on measuring multisystem quantitative traits that may be components of BP psychopathology may enable genetic dissection of this complex disorder, and investigation of extended pedigrees from genetically isolated populations may facilitate the detection of specific genetic variants that affect BP as well as its component phenotypes. OBJECTIVE To identify quantitative… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 16 times over the past 90 days. VIEW TWEETS