Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing

@article{Haag2011MultisubunitRP,
  title={Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing},
  author={Jeremy R. Haag and Craig S. Pikaard},
  journal={Nature Reviews Molecular Cell Biology},
  year={2011},
  volume={12},
  pages={483-492}
}
  • J. Haag, C. Pikaard
  • Published 1 August 2011
  • Biology
  • Nature Reviews Molecular Cell Biology
In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the myriad RNAs that are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, which orchestrate non-coding RNA-mediated gene silencing processes affecting development, transposon taming, antiviral defence and allelic crosstalk. Biochemical details concerning the templates and products of RNA polymerases IV and V are lacking. However, their… 
Plant Multisubunit RNA Polymerases IV and V
TLDR
This chapter discusses the state of the understanding of Pol IV and Pol V subunit compositions and functions, which play important roles in RNA-mediated gene silencing pathways that tame transposons, defend against invading viruses, mediate cross talk among alleles, and influence development.
Chapter 13 Plant Multisubunit RNA Polymerases IV and V
TLDR
This chapter discusses the state of the understanding of Pol IV and Pol V subunit compositions and functions, which play important roles in RNA-mediated gene silencing pathways that tame transposons, defend against invading viruses, mediate cross talk among alleles, and influence development.
RNA Polymerase III Advances: Structural and tRNA Functional Views.
Basic mechanism of transcription by RNA polymerase II.
Non-coding RNA transcription and RNA-directed DNA methylation in Arabidopsis.
TLDR
This review focuses on the mechanisms underlying the recruitment of Pol IV and Pol V to chromatin and the targeting of RdDM, which is responsible for transcriptional silencing of endogenous transposable elements and introduced transgenes.
RNA-Directed DNA Methylation: The Evolution of a Complex Epigenetic Pathway in Flowering Plants.
TLDR
Current views on the mechanism of RdDM are presented with a focus on evolutionary innovations that occurred during the transition from a Pol II transcriptional pathway, which produces mRNA precursors and numerous noncoding RNAs, to the Pol IV and Pol V pathways, which are specialized for RdDM and gene silencing.
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TLDR
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