Multisubstrate adduct inhibitors: Drug design and biological tools

  title={Multisubstrate adduct inhibitors: Drug design and biological tools},
  author={Pierre-B Le Calvez and Christopher J. Scott and Marie E. Migaud},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  pages={1291 - 1318}
In drug discovery, different methods exist to create new inhibitors possessing satisfactory biological activity. The multisubstrate adduct inhibitor (MAI) approach is one of these methods, which consists of a covalent combination between analogs of the substrate and the cofactor or of the multiple substrates used by the target enzyme. Adopted as the first line of investigation for many enzymes, this method has brought insights into the enzymatic mechanism, structure, and inhibitory requirements… 

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