Multistep activation of the Helicobacter pylori effector CagA.

  title={Multistep activation of the Helicobacter pylori effector CagA.},
  author={Anne Dorothee M{\"u}ller},
  journal={The Journal of clinical investigation},
  volume={122 4},
Chronic infection with the Gram-negative bacterium Helicobacter pylori is a major risk factor for the development of gastric cancer. Accumulating evidence indicates that the H. pylori virulence determinant cytotoxin-associated gene A (CagA) has a key oncogenic role in the process. Certain biological activities of CagA require its tyrosine phosphorylation by host cell kinases. In this issue of the JCI, Mueller and colleagues report their detailed kinetic and functional analysis of CagA… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…