Multistep Resistance Development Studies of Ceftaroline in Gram-Positive and -Negative Bacteria

@article{Clark2011MultistepRD,
  title={Multistep Resistance Development Studies of Ceftaroline in Gram-Positive and -Negative Bacteria},
  author={Catherine L. Clark and Pamela Mcghee and Peter C. Appelbaum and Klaudia Kosowska-Shick},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2011},
  volume={55},
  pages={2344 - 2351}
}
ABSTRACT Ceftaroline, the active component of the prodrug ceftaroline fosamil, is a novel broad-spectrum cephalosporin with bactericidal activity against Gram-positive and -negative isolates. This study evaluated the potential for ceftaroline and comparator antibiotics to select for clones of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecalis with elevated MICs. S. pneumoniae… Expand
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TLDR
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Identification of non-PBP2a resistance mechanisms in Staphylococcus aureus after serial passage with ceftaroline: involvement of other PBPs.
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  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • 2016
TLDR
These studies demonstrate that resistance to ceftaroline can be manifested through numerous mechanisms and support a hypothesis where PBP4 can functionally provide the essential transpeptidase activity required for MRSA cell wall biogenesis when PBP2a is inhibited. Expand
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Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin.
TLDR
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Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
TLDR
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In vitro activity of ceftaroline against multidrug-resistant Staphylococcus aureus and Streptococcus pneumoniae: a review of published studies and the AWARE Surveillance Program (2008-2010).
TLDR
Ceftaroline surveillance in the United States during 2008-2010 documented sustained potency and spectrum against multidrug-resistant S. aureus and multidrog- resistant S. pneumoniae known to cause ABSSSI and CABP. Expand
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