Multistep Modeling Strategy To Improve the Binding Affinity Prediction of PET Tracers to Aβ42: Case Study with Styrylbenzoxazole Derivatives.

Abstract

Positron emission tomography (PET) tracers play an important role in the diagnosis of Alzheimer's disease, a condition that leads to progressive dementia and memory loss. A high binding affinity and specificity of the PET tracers to amyloid oligomers and fibrils are crucial for their successful application as diagnostic agents. In this sense, it is… (More)
DOI: 10.1021/acschemneuro.6b00216

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Cite this paper

@article{Balamurugan2016MultistepMS, title={Multistep Modeling Strategy To Improve the Binding Affinity Prediction of PET Tracers to Aβ42: Case Study with Styrylbenzoxazole Derivatives.}, author={Kanagasabai Balamurugan and Natarajan Arul Murugan and Hans {\AA}gren}, journal={ACS chemical neuroscience}, year={2016}, volume={7 12}, pages={1698-1705} }