Multistate protein design using CLEVER and CLASSY.

  title={Multistate protein design using CLEVER and CLASSY.},
  author={Christopher Negron and Amy E. Keating},
  journal={Methods in enzymology},
Structure-based protein design is a powerful technique with great potential. Challenges in two areas limit performance: structure scoring and sequence-structure searching. Many of the functions used to describe the relationship between protein sequence and energy are computationally expensive to evaluate, and the spaces that must be searched in protein design are enormous. Here, we describe computational tools that can be used in certain situations to provide enormous accelerations in protein… CONTINUE READING