Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.

Abstract

Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.