Multistability in a model for CTL response to HTLV-I infection and its implications to HAM/TSP development and prevention.

@article{GmezAcevedo2010MultistabilityIA,
  title={Multistability in a model for CTL response to HTLV-I infection and its implications to HAM/TSP development and prevention.},
  author={Horacio G{\'o}mez-Acevedo and Michael Y. Li and Steven Jacobson},
  journal={Bulletin of mathematical biology},
  year={2010},
  volume={72 3},
  pages={681-96}
}
Human T-cell leukaemia/lymphoma virus type I (HTLV-I) is a retrovirus that has been identified as the causative agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other illnesses. HTLV-I infects primarily CD4(+) T cells and the transmission occurs through direct cell-to-cell contact. HAM/TSP patients harbor higher proviral loads in peripheral blood lymphocytes than asymptomatic carriers. Also, HAM/TSP patients exhibit a remarkably high number of circulating HTLV-I… CONTINUE READING

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