Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients.

@article{Mezheyeuski2018MultispectralIF,
  title={Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients.},
  author={Artur Mezheyeuski and Christian Holst Bergsland and Max Backman and Dijana Djureinovic and Tobias Sj{\"o}blom and Jarle Bruun and Patrick Micke},
  journal={The Journal of pathology},
  year={2018},
  volume={244 4},
  pages={
          421-431
        }
}
Semiquantitative assessment of immune markers by immunohistochemistry (IHC) has significant limitations for describing the diversity of the immune response in cancer. Therefore, we evaluated a fluorescence-based multiplexed immunohistochemical method in combination with a multispectral imaging system to quantify immune infiltrates in situ in the environment of non-small-cell lung cancer (NSCLC). A tissue microarray including 57 NSCLC cases was stained with antibodies against CD8, CD20, CD4… CONTINUE READING
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