Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2.

@article{Takeuchi2001MultispecificSR,
  title={Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2.},
  author={Akiyo Takeuchi and Setsuko Masuda and Hikaru Saito and Tomoyuki Abe and Ken Inui},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={299 1},
  pages={261-7}
}
We characterized the interactions of various compounds with OAT-K1 and OAT-K2, kidney-specific organic anion transporters. By using Madin-Darby canine kidney cells stably transfected with OAT-K1 or OAT-K2 cDNA, the antitumor drug methotrexate, the mycotoxin ochratoxin A, endogenous organic anions (thyroid hormones, taurocholic acid, and conjugated steroids), and the antiretroviral drug zidovudine were shown to be substrates for these transporters. Although the apparent Michaelis constant (Km… CONTINUE READING
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