Multisite intracerebral microdialysis to study the mechanism of L-DOPA induced dopamine and serotonin release in the parkinsonian brain.

@article{Navailles2013MultisiteIM,
  title={Multisite intracerebral microdialysis to study the mechanism of L-DOPA induced dopamine and serotonin release in the parkinsonian brain.},
  author={Sylvia Navailles and M{\'e}lanie Lagi{\`e}re and Andrea Contini and Philippe De Deurwaerd{\`e}re},
  journal={ACS chemical neuroscience},
  year={2013},
  volume={4 5},
  pages={680-92}
}
L-DOPA is currently one of the best medications for Parkinson's disease. It was assumed for several years that its benefits and side effects were related to the enhancement of dopamine release in the dopamine-depleted striatum. The use of intracerebral microdialysis combined with a pharmacological approach has led to the discovery that serotonergic neurons are responsible for dopamine release induced by L-DOPA. The subsequent use of multisite microdialysis has further revealed that L-DOPA… CONTINUE READING
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