Multiscale tissue engineering for liver reconstruction

  title={Multiscale tissue engineering for liver reconstruction},
  author={Ryo Sudo},
  pages={216 - 224}
  • R. Sudo
  • Published 5 February 2014
  • Biology
  • Organogenesis
The liver is a target of in vitro tissue engineering despite its capability to regenerate in vivo. The construction of liver tissues in vitro remains challenging. In this review, conventional 3D cultures of hepatocytes are first discussed. Recent advances in the 3D culturing of liver cells are then summarized in the context of in vitro liver tissue reconstruction at the micro- and macroscales. The application of microfluidics technology to liver tissue engineering has been introduced as a… 

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  • Biology, Engineering
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The fundamental concepts of whole-organ engineering, including characterization of the extracellular matrix as a scaffold, methods for decellularization of vascular organs, potential cells to reseed such a scaffolds, techniques for the recellularization process and important aspects regarding bioreactor design to support this approach are described.

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Decellularization for whole organ bioengineering.

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